Zhou Lab @iHUman

About our lab
Welcome to Zhou lab

The Zhou Lab studies how neuronal function is disrupted by neurological and mental disorders at the cellular and network level.

Our approaches include using techniques of two-photon fluorescence imaging, in vivo Ca2+ imaging with miniature endoscopes, and patch clamp recordings

We are interested in (1) functional alterations of local neuronal networks in normal and diseased brain; (2) interaction between neurons and glial cells; and (3) electrophysiological and neurovascular changes following spreading depolarization and acute brain injuries.…

 

Projects
Two photon
Two-photon Microscopy

In our lab, we utilized two-photon microscopy to investigate the function of Posterial Parietal Cortex, which receives input from a collection of sensory areas as well as a variety of other regions of the brain, and is thought to integrate that input to facilitate the execution of functions that require diverse information.

mice
Miniature Endoscope

Miniscope allows us to wirelessly and non-invasively monitor neural activity in CA1 region of hippocampus over multi-month periods. Researchers could study neural ensemble while the mice are performing behavioral tasks.

Electrophysiological recording

Patch clamping is one of the electrophysiological recording techniques used in the lab. The basic mechanism of it is to use a micropipette attached to the cell membrane to allow recording from a single ion channel or few channels.